Surfactant protein c deficiency hydroxychloroquine

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  1. ILLIA Well-Known Member

    Surfactant protein c deficiency hydroxychloroquine

    The exact physiopathology of this disease is not known and there is no specific treatment for it. There is merely news from a few previous descriptions in the literature about the use of hydroxychloroquine for surfactant protein C deficiency with satisfactory results.

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    Amin et al. 2001 reported the benefit of treatment with hydroxychloroquine for surfactant protein C deficiency. Tredano et al. 2004 and Brasch et al. 2004 reported successful treatment with repeated whole-lung lavage, systemic corticosteroids, and azathioprine. The SFTPC gene provides instructions for making a protein called surfactant protein-C SP-C. This protein is one of four proteins each produced from a different gene in surfactant, a mixture of certain fats called phospholipids and proteins that lines the lung tissue and makes breathing easy. SFTPC surfactant protein C mutations resulting in SP-C deficiency causing ongoing respiratory failure in the neonatal period represent a rare entity. We report a full-term female infant who.

    These data seem to cast some doubt on the efficacy of hydroxychloroquine, and they suggest that the clinical improvement was simply the natural evolution of the disease. Two years after the treatment was withdrawn, the twins were evaluated once again: they presented no new infections, growth and general state were normal and chest CT showed a notable additional reduction in the interstitial pneumopathy.

    Surfactant protein c deficiency hydroxychloroquine

    ABCA3 Transporter Deficiency American Journal of., SFTPC gene - Genetics Home Reference - NIH

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  4. Subsequently, surfactant protein gene analysis revealed mutations in the ABCA3 gene. This case of ABCA3 deficient ILD describes a stable clinical course over 10 years and highlights the potential benefit of hydroxychloroquine for this condition.

    • Ten-year follow up of hydroxychloroquine treatment for..
    • Successful treatment of neonatal respiratory failure..
    • Hydroxychloroquine and Surfactant Protein C Deficiency Request PDF.

    The diagnosis of a surfactant protein C mutation c.545 GC.pGly182Arg was confirmed by genetic testing once available. Patient 1 had a family history of a maternal uncle dying of pneumonia at 6 months of age and a maternal grandfather dying of lung disease at 49 years of age, but neither one had genetic studies performed. Surfactant protein C deficiency is characterised by deficiency of the protein and its intracellular accumulation, with subsequent local inflammation and interstitial lung disease. There is no specific treatment, but hydroxychloroquine has been reported to be effective. To the Editor We wish to report initial success in treating a boy with surfactant protein C deficiency. The patient was first admitted to the hospital at five months of age with severe respiratory.

  5. netangels XenForo Moderator

    The page you are trying to reach is not available on our site. The page name may have changed, you may have happened upon a broken link, or the URL may be entered incorrectly. Hydroxychloroquine Oral Tablet Drug Information, Side. Oral Dosage Forms That Should Not Be Crushed Institute For. What Is Hydroxychloroquine Used For?
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    PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION Hydroxychloroquine sulfate sulfate base, and are for oral PLAQUENIL® HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION PLAQUENIL h. ydroxychloroquine sulfate is a. white or practically white, crystalline. powder freely. soluble in water; practically insoluble in alcohol, chloroform, and in ether. The. chemical. name for

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  7. Natasha_K Well-Known Member

    Hydroxychloroquine Oral Uses, Side Effects, Interactions. Find patient medical information for Hydroxychloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

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