Most importantly, you help support continued development of this site. The majority of cases of retinotoxicity have occurred in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine (Plaquenil). This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day (200 bid). Hydroxychloroquine diagnostic studies Plaquenil and artemisia annua together Hydroxychloroquine cost at costco Plaquenil eye exam standard of care Per the prior 2011 AAO guidelines the recommended maximum dose to minimize HCQ retinal toxicity was 6.5 mg /kg based on ideal body weight 2. The advantage of the real body weight formula is that it distributes the risk evenly on a broad range of body habitus. This apparently resulted in overdosing of thin patients. Thus, the patient’s real weight is now recommended as the basis for calculating the daily dose per weight in kg. Doses ≥ 5 mg/kg/day real weight of hydroxychloroquine 2.3 mg/kg/day of chloroquine are associated with higher risk of toxicity. Nov 25, 2019 Suppression 5 mg/kg calculated as base orally on exactly the same day each week; the dose should not exceed 400 mg regardless of weight Comments-Suppressive therapy should begin 2 weeks prior to exposure; however, failing this, an initial dose of 10 mg/kg calculated as base may be taken in 2 divided doses 6 hours apart. It now solely uses real body weight (rather than ideal body weight) based on new recommendations from a 2014 study (1). Disclaimer: This tool is designed to help eye care professionals better understand the risk the of retinotoxicity from hydroxychloroquine. Please note: This calculator was modified in 9/2015. Hydroxychloroquine dose per kg Hydroxychloroquine Plaquenil Toxicity and Recommendations., Hydroxychloroquine And Chloroquine Screening 2016 AAO. Chloroquine highQuinine chloroquine side effects Jul 05, 2018 Correspondingly, the median HCQ dose per IBW declined from 6.0 mg/kg to 5.7 mg/kg during the study period, and the median HCQ dose per ABW declined from 4.4 mg/kg to 4.1 mg/kg both p values 0.01 Fig. 1. Hydroxychloroquine prescription trends and predictors for.. Hydroxychloroquine Dosage Guide with Precautions -. Hydroxychloroquine Plaquenil. However, dose is usually not more than 800 mg for the first dose and not more than 400 mg for the next doses. Children—Dose is based on body weight and must be determined by your doctor. At first, 13 mg per kg of body weight taken as a single dose. Then, 6.5 mg per kg of body weight taken 6 hours, 24 hours, and 48 hours after the first dose. Mar 17, 2019 1.5 to 15 years 7 mg/kg orally per day added to first course treatment for JDMS if the patient presented with extensive skin rash and needed steroids in high doses Each dose should be taken with a meal or a glass of milk. What other drugs will affect hydroxychloroquine? Jan 05, 2020 Hydroxychloroquine retinopathy is most influenced by daily dose and duration of use. Risk for toxicity is less with 5.0 mg/kg real weight/day for hydroxychloroquine and 2.3 mg/kg real weight/day for chloroquine. Patients are at low risk during the first 5 years of treatment.