I can't say that the drug has helped at all, but it is difficult to compare todays pain with that of 6 months ago. Still get mysterious rashes, fevers and other odd symptoms. Asked my primary to check my thyroid after taking a bovine herbal thyroid med for 2 weeks. Then they worked out it was my liver causing my liver and that I could go back on Plaquenil. I have gained nearly 25 lbs now and I can' t stand it, but when I try an dexercise it is as if my muscles just will not relax, the are tight and it hurts to even do the lightest yogo! I took 60mg for a year and only 30 this past month. NOw if my thyroid isn't working I've hidden it from my dr... Well, within 3 days my non-liver symptoms were way better. Stopping plaquenil Starting plaquenil during pregnancy Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur. Talk to your doctor about this, but my guess is that the Plaquenil is not doing anything to cause the pain, but rather that it is not doing enough to prevent it. It sounds like your RA has probably gotten a bit out of control, relative, to your current treatment, and Plaquenil is not a particularly potent drug when it comes to managing joint pain. I saw a rheumatologist who said "no the nausea is at the start before you get use to it etc, but just come off it for 2 weeks to 'prove this doctor wrong'". Don't know what I was thinking but my thyroid showed 1.59 (0,47-4.68)... Since then I've had one flare up of my hips and finger joints, which lasted for about 2-3 days (typically my flares last a few weeks). I'd say they're 90-95% better than this time last year. Plaquenil cause muscle pain How Lupus Affects the Muscles, Tendons and Joints Lupus., Plaquenil Side Effects Common, Severe, Long Term - Plaquenil coupons discountsHydroxychloroquine stomach ulcerCan plaquenil help with butterfly rashChloroquine-primaquine-phosphate tabletsPlaquenil safer than floroquinolones In rare cases, Plaquenil can cause cardiomyopathy, a chronic disease of the heart muscle. If you're taking Plaquenil for an autoimmune condition, your symptoms should begin to improve after a few. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Plaquenil and pain" Rheumatoid Arthritis Community.. Can Plaquenil cause Muscle Weakness? - Treato. I agree with CameronC and all others who are "pro" Plaquenil. I was diagnosed with Limited Systemic Scleroderma in late 2001 & started Plaquenil at the beginning of 2002. Joint and muscle pain and overwhelming fatigue were my worst symptoms. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Do you still have joint and muscle pain on plaquenil? I've been on plaquenil for 6 months now and I still have significant joint pain! I can't say that the drug has helped at all, but it is difficult to compare todays pain with that of 6 months ago.