Chloroquine cancer treatment

Discussion in 'Hydroxychloroquine' started by Borger, 28-Feb-2020.

  1. MADMAN New Member

    Chloroquine cancer treatment


    The answer, if it’s the answer, is not an obvious one: it seems to be interfering with cholesterol biosynthesis. Chloroquine’s effects on bladder cancer cell lines, it turns out, can be shut down by providing the cells with extra cholesterol, and those effects can be recapitulated by giving them statin drugs or disrupting their cholesterol synthesis pathways by RNA interference.

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    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. ovale, and P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. This medicine may add to the chance of getting some types of cancer. Talk with the doctor. Keep away from children. Accidental exposure may cause death. If a child takes chloroquine by accident, get medical help right away. If you are 65 or older, use chloroquine with care. You could have more side effects. Chloroquine and Cancer Treatment Chloroquine has long been used to treat or prevent malaria. Chloroquine is also used to treat autoimmune diseases in some countries because of its immunosuppressive properties.

    (That link takes you to a full-text review which will get you up to speed, should you desire). The mechanism seems to involve lysosomal cell death, which until recently has been a little-appreciated process.

    Chloroquine cancer treatment

    Chloroquine in Cancer Therapy A Double-Edged Sword of Autophagy., Chloroquine Indications, Side Effects, Warnings -

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  3. Nov 24, 2017 Chloroquine and hydroxychloroquine are drugs that are used to treat malaria, but a new review suggests that they may have another purpose treating cancer. Share on Pinterest Two antimalarial.

    • Malaria drugs could help to combat cancer.
    • Chloroquine in Cancer Therapy A Double-Edged Sword of..
    • Chloroquine Oral Uses, Side Effects, Interactions, Pictures, Warnings..

    Chloroquine CQ is a 4-aminoquinoline drug used for the treatment of diverse diseases. It inhibits lysosomal acidification and therefore prevents autophagy by blocking autophagosome fusion and degradation. Mar 20, 2019 The study provides evidence that using chloroquine in combination with an inhibitor of the replication stress response pathway could be a new treatment to reduce tumor growth in pancreatic cancer. There is a growing evidence that antimalarial chloroquine could be re-purposed for cancer treatment. A dozen of clinical trials have been initiated within the past 10 years to test the potential of chloroquine as an adjuvant treatment for therapy–refractory cancers including glioblastoma, one of the most aggressive human cancers.

     
  4. searchers9 User

    The anion gap is a value that’s calculated using the results of an electrolyte blood test. Anion Gap - an overview ScienceDirect Topics Anion Gap Blood Test Why You May Need It and Test Result Meanings Diabetic Ketoacidosis Evaluation and Treatment
     
  5. nemchilo User

    Malaria Prophylaxis. The ABCD of Malaria Prophylaxis. Chloroquine. Chloroquine is used for the prophylaxis of malaria in areas of the world where the risk of chloroquine-resistant falciparum malaria is still low. It is also used with proguanil when chloroquine-resistant falciparum malaria is present. However, this combination may not be ideal.

    Malaria Information and Prophylaxis, by Country S - CDC
     
  6. dead mahno Well-Known Member

    Plaquenil - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol. Take this medication with a meal or a glass of milk to prevent stomach upset. Common side effects include nausea, loss of appetite, headache, and diarrhea. Plaquenil can cause blurred vision and dizziness. Do not drive or operate heavy machinery until you know how it affects you.

    Plaquenil Side Effects on Your Eyes and Vision