Listing a study does not mean it has been evaluated by the U. Most cases of RPL are unexplained and have no effective treatment to improve the chance of a live birth. Exciting indications for using Hydroxychloroquine (HCQ) include: Malaria profylaxis and treatment, systemic and discoid lupus erythematosus (SLE) and rheumatoid athritis (RA). Plaquenil use during pregnancy Non aqueous titration of chloroquine In majority cases, the actual cause of miscarriage is not known. Therefore, we call this condition as unexplained recurrent pregnancy loss. 50% to 75 % of cases of recurrent miscarriages are unexplained. In other cases, here are some of the causes Chromosomal abnormalities. Endocrine disorders. Immunological factors. Ovarian factors. Many women with systemic lupus erythematosus SLE take hydroxychloroquine HCQ to control disease activity. Studies have shown that HCQ can prevent renal and central nervous system lupus and lessen the effects of SLE 1, 2. This summary, the second segment of this two-part presentation, focuses on antiphospholipid syndrome. For more information on lupus, please read Recent Developments in Managing and Treating Lupus and Antiphospholipid Syndrome APS Part I – Lupus. There is no data concerning the benefit of HCQ in RPL. HCQ has been reported to have the following properties (anti-thrombotic, vascular-protective, immunomodulatory, improving glucose tolerance, lipid-lowering, and anti-infectious). Hydroxychloroquine prevent miscarriage Hydroxychloroquine may be beneficial in preeclampsia and., Hydroxychloroquine in lupus pregnancy - Clowse - 2006. Sd-oct and plaquenil toxicityChloroquine therapeutic classCan you take doxe-pin hcl and hydroxychloroquine 200 mg to A woman who suffered 20 miscarriages over 10 years, has had a baby boy after being given a drug normally used to treat malaria and rheumatoid arthritis. Kelly Moseley, from Birmingham, endured 11 miscarriages each at about eight weeks before she contacted a miscarriage expert she had seen on television. Baby born to woman who suffered 20 miscarriages - BBC News. Managing and Treating Lupus and Antiphospholipid Syndrome.. Hydroxychloroquine and Unexplained Recurrent Miscarriage.. Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. Posts RE Plaquenil Hydroxychloroquine during pregnancy Posted on Jan 9, 2015 at pm not the first line for NK cells but seems to have benefits there and for those with autoantibody mediated syndromes. Mechanism of action still unclear. In most cases, there's nothing you can do to cause a miscarriage, and nothing you can do to prevent it, says Siobhan Dolan, M. D. a medical advisor to the March of Dimes and an attending physician.