It works by preventing or treating malaria, a red blood cell infection transmitted by the bite of a mosquito. However, this medicine is not used to treat severe or complicated malaria. Is hydroxychloroquine sulfate an immunosuppressive drug Will plaquenil help with fatigue Plaquenil and cataracts May 23, 2016 Other potential side effects include but are not limited to nausea, changes in mood, muscle weakness, skin pigmentation and anemia. While the drug may be used during pregnancy, the potential benefits and risks should be discussed with your doctor. In summary, if you have Sjögren’s, hydroxychloroquine may be an option to help your symptoms. Diagnosis of Drug-induced Myopathies. A drug-induced, or toxic, myopathy is defined as the acute or subacute manifestation of myopathic symptoms such as muscle weakness, myalgia, creatine kinase CK elevation, or myoglobinuria that can occur in patients without muscle disease when they are exposed to certain drugs. Apr 28, 2009 This is a new question concerning an old post. Plaquenil and muscle pain. I thought that maybe my question had been answered when I read that Plaquenil was responsible for your muscle pain but, as I read on I realize it was not. I TOO have severe muscle pain and cramping in my legs. Only when trying to sleep. It is also used to treat acute and chronic rheumatoid arthritis. Hydroxychloroquine is used to treat discoid lupus erythematosus (DLE) or systemic lupus erythematosus (SLE or lupus). Plaquenil muscle weakness Hydroxychloroquine Side Effects, Dosage, Uses, and More, Drug-related Myopathies of Which the Clinician Should Be Aware Is plaquenil safe to take while breastfeeding Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Rarely, hydroxychloroquine can lead to anemia in PATIENT FACT SHEET Hydroxychloroquine Plaquenil. Plaquenil and muscle aches and pains?. Plaquenil and muscle weakness - Sjogren's World. Muscle weakness also may be a side effect of certain drugs used to treat lupus and related conditions, including prednisone and other corticosteroids, cholesterol-lowering drugs and hydroxychloroquine Plaquenil®. Therefore, drug-induced muscle disease should be ruled out as a cause of weakness if you are taking any of these medications, as drug-induced muscle weakness usually does not produce elevated levels of muscle enzymes as is seen in lupus myositis. General feeling of tiredness or weakness headache inability to move the eyes increased blinking or spasms of the eyelid joint or muscle pain large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, and sex organs loss of hearing lower back or side pain noisy breathing painful or difficult urination Muscle weakness; Bleeding or bruising of the skin; Irregular heartbeat; Mood or mental changes, such as confusion or other changes in thinking, feelings, or behavior; Bleaching or loss of hair.