Chloroquine treatment in pregnancy

Discussion in 'Health Canada Drug Database' started by saboxeetor, 16-Mar-2020.

  1. MineHost Well-Known Member

    Chloroquine treatment in pregnancy


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Malaria treatment oral To treat malaria in adults, one dose of oral chloroquine is usually given right away. Then, half the dose is taken six to eight hours later. This is typically followed by half the dose once a day for the next two days. Amebiasis treatment oral To treat amebiasis in adults. We postulated that intermittent preventive treatment in pregnancy with chloroquine or weekly chloroquine chemoprophylaxis would be superior to intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine in preventing placental malaria infection and the maternal and newborn adverse effects of pregnancy-associated malaria. Chloroquine appears to be more retinotoxic than hydroxychloroquine. Screening recommendations for chloroquine All patients planning to be on long-term treatment should receive a baseline examination including fundus photography and spectral domain optical coherence tomography within 6-12 months of treatment initiation;

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine treatment in pregnancy

    The Safety of Antimalarial Drugs in Pregnancy SpringerLink, Chloroquine as weekly chemoprophylaxis or intermittent.

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  6. Usage of Chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus. Radioactively tagged Chloroquine administered intravenously to pregnant pigmented CBA mice passed rapidly across the placenta and accumulated selectively in the melanin structures of the fetal eyes.

    • Chloroquine - FDA prescribing information, side effects..
    • CHLOROQUINE Drug BNF content published by NICE.
    • Chloroquine - FDA prescribing information, side effects and uses.

    However, if the P. falciparum is known to be resistant to chloroquine as it is in many parts of the world, chloroquine would not be an appropriate treatment. WHO recommends that women in the first trimester of pregnancy with uncomplicated malaria receive 7 days of quinine with clindamycin. Chloroquine is also used for prophylaxis for pregnant women and non-immune individuals at risk. Dosage and administration. All dosages are described in terms of the base. Treatment. Oral administration. To avoid nausea and vomiting chloroquine should be administered after meals. Chloroquine use in pregnancy has not been shown to cause a baby to be born early in any of the four studies that have investigated this. Studies have, however, shown that preterm birth is more common in pregnant women with malaria infection.

     
  7. kravovich Well-Known Member

    Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Plaquenil, Plaquenil Sulfate, Quineprox hydroxychloroquine. Hydroxychloroquine Reviews Everyday Health Hydroxychloroquine Uses, Dosage & Side Effects -
     
  8. Danila Well-Known Member

    Methotrexate and plaquenil - Hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works.

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