Chloroquine excretion

Discussion in 'Chloroquine Drug' started by Kirill-CASH, 05-Mar-2020.

  1. v.v pukin Well-Known Member

    Chloroquine excretion


    Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems.

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    Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract. Excretion of chloroquine is quite slow, but is increased by acidification of the urine. Slightly more than half of the urinary drug products can be accounted for as unchanged chloroquine. Large i.m. injections or rapid i.v. Chloroquine was assayed in the semen of eight male volunteers aged between 19 and 45 years by a fluorimetric method before and after taking a total dose of 1.500 mg chloroquine base. Chloroquine undergoes appreciable degradation in the body. The main metabolite is desethylchloroquine, which accounts for one fourth of the total material appearing in the urine; bisdesethylchloroquine, a carboxylic acid derivative, and other metabolic products as yet uncharacterized are found in small amounts.

    For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor.

    Chloroquine excretion

    Chloroquine - Safe In Breastfeeding, Ghloroquine excretion in semen following antimalarial‚Äźdrug.

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  4. The excretion of chloroquine and the major metabolite, desethylchloroquine, in breast milk was investigated in 11 lactating mothers following a single oral dose of chloroquine 600 mg basemaximum daily dose of the drug that the infant received from breast-feeding was about 0.7% of the maternal start dose.

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    Hydroxychloroquine can be detected in the cord blood at delivery in concentrations similar to those in the maternal serum Costedoat-Chalumeau 2002. In animal reproduction studies with chloroquine, accumulation in fetal ocular tissues was observed and remained for several months following drug elimination from the rest of the body. Excretion of chloroquine is quite slow, but is increased by acidification of the urine. Chloroquine is deposited in the tissues in considerable amounts. In animals, from 200 to 700 times the plasma concentration may be found in the liver, spleen, kidney, and lung; leukocytes also concentrate the drug. The excretion of chloroquine and the major metabolite, desethylchloroquine, in breast milk was investigated in eleven lactating mothers following a single oral dose of chloroquine 600 mg base. The maximum daily dose of the drug that the infant can receive from breastfeeding was about 0.7% of the maternal start dose of the drug in malaria chemotherapy.

     
  5. maksik_k User

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine synergizes with FTS to enhance cell growth. Pitfalls of the MTT assay Direct and off-target effects of. PDF CHLOROQUINE SUPPRESSES GLIOMA CELL VIABILITY AND.
     
  6. lor2 User

    Common and Rare Side Effects for Plaquenil Oral Find information about common, infrequent and rare side effects of Plaquenil Oral.

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  7. Hydroxychloroquine plaquenil withdrawl? - LUPUS UK I don't know if anyone can help as this isn't technically lupus related. I've been on plaquenil for 6 months for suspected Sjogren's syndrome I don't have antibodies for Sjorgren's or Lupus but I do have Hashimoto's and have all the symptoms for Sjorgren's so the rheumatologist suggested a trial of plaquenil.

    Hydroxychloroquine Plaquenil Side Effects & Dosage for.