Oftentimes, you can reduce your risk for future bruising by making sure you’re getting the right nutrients in your diet. Read on to learn more about common causes, what to watch for, and when to see a doctor. Plaquenil sjogren& 39 What side effects does plaquenil have on your teeth I've taken Plaquenil for aprx 9 years. I have many complications w the diseases themselves but i bruise very easily. I also notice bruises that I cant explain. They all seem to be extra sore and very bright blue. I've ask my RA Dr about this but never a understandable explanation. Most of my bruising is found on my arms, hands and lower legs. Hydroxychloroquine can be taken with a glass of milk or a meal to decrease nausea. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take hydroxychloroquine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Aug 14, 2017 Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. If you’ve recently overdone it at the gym, you may develop bruises around the affected muscles. Intense exercise can leave you with more than just sore muscles. Can plaquenil cause bruising Random Bruising 13 Possible Causes Excluding Obvious Injury, Hydroxychloroquine MedlinePlus Drug Information Hydroxychloroquine pregnancyEster c and plaquenilChloroquine for treating malaria Hydroxychloroquine - oral, Plaquenil. severe nausea/vomiting, easy bleeding/bruising, signs of infection e.g. fever, persistent sore throat. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more medication should not be used if you have. HYDROXYCHLOROQUINE - ORAL Plaquenil side effects.. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. I know bruising can be related to a blood thing. Low blood counts can cause this so it may be something you need to bring to your doc. I'm not sure if Plaquenil lowers blood counts or not. I know since I'm on Methotrexate I have to keep an eye on this because it can lower my blood counts. In rare cases, Plaquenil can cause cardiomyopathy, a chronic disease of the heart muscle. If you’re taking Plaquenil for an autoimmune condition, your symptoms should begin to improve after a few months, but it can take up to six months for full effects. Stop taking the medicine and call your doctor if your symptoms worsen or don’t improve.